Biochemistry - How BSE Occurs at a Molecular Level Coursework

Biochemistry - How BSE Occurs at a Molecular Level - Coursework Example Toxicity: Large amounts of phenylalanine taken in the form of nutritional supplements elevate blood pressure. Symptoms such as headaches, heartburn and nausea may be experienced. In addition, the nervous system is usually affected by the toxicity of phenylalanine. Reactivity: Phenylalanine is a hydrophobic amino acid with an aromatic side chain. Therefore, it is fairly unreactive and mostly takes place in substitution reactions where it is interchanged with amino acids of a similar nature. Consequently, it plays a key role in substrate recognition rather than in protein function. Hydrogen bonds: Hydrogen atoms from the amine groups are pulled towards the electronegative carboxyl groups leading to sharing of electrons. The repetitive nature of such attractions within the protein structure confers stability. Van der Waals forces: Interactions among induced dipoles that form from the changes in charge density that occur in adjacent atoms that do not necessarily form a bond constitute attractive van der Waals forces. Repulsive forces, on the other hand, entail interactions between atoms that come close to each other but do not form dipoles. The huge numbers of such forces within the structure of proteins affect the stability of proteins. When certain proteins fail to fold in the required way, they begin to cluster and form aggregates. These aggregates contain certain polymeric structures such as beta sheets. In BSE, these aggregates are in the form of prions, which get into the brain and cause disease. Prions are proteinaceous infectious particles that comprise aggregates of misfolded proteins. Prions alter the structure of the brain by stimulating the formation of ‘holes’ in the brain, which ultimately give the brain a spongy architecture. Consequently, the nervous system is affected making the cow behave abnormally.  Ingestion of prions present in contaminated food causes them to be taken up into the body.  Ã‚